Tuesday, January 22, 2008

SF Castro District Epicenter of New Strain of Staph Bacteria


A new variety of staph bacteria, highly resistant to antibiotics and possibly transmitted by sexual contact, is spreading among gay men in San Francisco, Boston, New York and Los Angeles, researchers reported Monday.

The study released online by the journal Annals of Internal Medicine found the highest concentrations of infection by the drug-resistant bug in and around San Francisco's Castro district and among patients who visit health clinics that treat HIV infections in gay men in San Francisco and Boston.

The culprit is a form of MRSA, or methicillin-resistant Staphylococcus aureus, a bug that was once confined to hospitalized patients but, since the late 1990s, has been circulating outside medical settings, afflicting anyone from injection-drug users to elementary school students.

A strain called USA300 has been a leading cause of MRSA infection in this decade, and an exceptionally drug-resistant variant of it is now on the loose, researchers say.

The study estimated that 1 in 588 residents living within the Castro neighborhood 94114 ZIP code area is infected with that variant, which is resistant to six types of commonly used antibiotics. The risk of contracting this difficult-to-treat bug is 13 times greater for gay men than for the rest of the city's population, researchers found.

"We probably had it here first, and now it is spreading elsewhere," said Binh An Diep, a researcher at San Francisco General Hospital and lead author of the report. "This is a national problem, and San Francisco is at the epicenter."

The germ typically causes boils and other skin and soft-tissue infections and, despite its resistance to some drugs, is still treatable by surgical drainage and several classes of antibiotics. What is unusual in this case is the high percentage of infections - up to 40 percent - occurring in the buttocks and genitalia.

Although researchers have stopped short of declaring this form of staph a sexually transmitted disease, the infections are found where skin-to-skin contact occurs during sexual activity.

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